Isabella never sets foot in the New World, but she is the source of everything that happens there. Rodrigo arrives on Kahhori's land in her name, claiming the Fountain of Youth for the Spanish crown, and the violence that follows traces directly back to her authority and her appetite. She is the architecture of the invasion even in her absence.

When Kahhori has broken the conquistadors and freed her people, she does not stop there. She takes the fight to Isabella directly, traveling to Spain and arriving in the throne room with the full force of what the Tesseract has made her. When Isabella falls back on the language of divine ordination, declaring herself appointed to rule over lands and people she has never seen, Kahhori lifts her physically out of her throne and then destroys the throne itself. The message is not subtle and is not meant to be. Isabella is being shown, in terms she cannot argue with, exactly what the balance of power looks like now. Whether she chooses peace or faces something considerably worse is the choice being put to her. Strange Supreme steps through a portal before her answer comes, leaving the queen suspended in that moment of reckoning.